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In consultation with a sickle cell expert, transfuse people who have acute splenic sequestration and severe anemia to raise the hemoglobin to a stable level, while avoiding over-transfusion.

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In a proof-of-principle test of BCL11A as a potential therapeutic target, demonstrated that inactivation of BCL11A in sickle cell disease transgenic mice corrects the hematologic and pathologic defects associated with sickle cell disease through high-level pancellular HbF induction.

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This article summarizes the role of vascular inflammation and coagulation activation, discusses potential mechanisms responsible for activation of coagulation and reviews recent data demonstrating the crosstalk between coagulation and vascular inflammation in sickle cell disease.

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The frequency, severity, location and duration of pain crises can vary considerably, even within a specific disease subtype.

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The Orange County medical examiner found that symptoms associated with sickle-cell trait caused UCF football player Ereck Plancher to collapse and die after an off-season workout on March 18.

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